When making pills, all solids are turned into the finest powder. The order of mixing them is the same as when preparing complex powders. If the pills contain poisonous and potent substances, then they are previously dissolved in water or ethanol.

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The finished pill mass is weighed, the amount of mass is indicated in the recipe and the written control passport and transferred to a pill machine (Fig.20.1). The pill machine consists of a wooden machine with frosted glass, two cutters, a wooden board for rolling out the rod and a roller (mug) for rounding the cut pills. Cutters are made of stainless steel, aluminum, plastic and are used depending on the chemical properties of the ingredients that make up the pill mass.

The prepared and weighed mass is rolled out into a stick of such length that it fits exactly between the ends of the cutter. The number of grooves on both sides of the cutter is 30, but they are different sizes. If more than 30 pills are prescribed, then the rod is cut into 2-3 equal parts and the corresponding number of pills is rolled out from each part.

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The height of medrol roller flange should match the size of the pill.

The finished pills should be the same, round, smooth and bounce off the board when dropped from a height of 10-15 cm.

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During the preparation of pills, do not touch the pill mass, the rod, or the finished pills with your hands. The pill stick is taken with a piece of waxed paper. To keep the pills from slippingThey were among themselves, according to the instructions of the GPC, they are sprinkled with lipodium or starch, and pills with oxidizing agents (silver nitrate or potassium permanganate) are sprinkled with white clay.

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The suggestion to sprinkle the pills in the recipe is indicated by the words: consperge - sprinkle; conspergatur - let them be sprinkled; consperge Amylo (Lycopodio) - medrol with starch (Lycopodio).

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Medrol Pills with insoluble and hardly soluble substances. For example: 20.5. Rp .: Acidi arsenicosi anhydrici 0.03 Phytini 3.0 Massae pilularum q. s., ut fiant pilulae N. 30 DS. 1 pill 3 times a day. Arsenous anhydride is soluble in 65 parts of water, phytin is almost insoluble.

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Thus, the solid phase of the pill mass consists of the medicinal substances themselves. The liquid phase can be created using some plant extract, such as licorice, but it is customary to make all pills with arsenic white ("white pills"). In this regard, it will be appropriate to use wheat flour as a binding agent, and glycerin water or sugar syrup for wetting.

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The pores of the mortar are rubbed with a small amount of phytin, which is then thoroughly mixed with arsenous anhydride (trituration 1:10). The resulting mixture is diluted with the rest of the phytin, moistened with syrup and compacted with flour, crushing until a plastic mass lagging behind the mortar and pestle is obtained. If the mass turned out to be soft, then you can add a little starch. The resulting pills are sprinkled with starch.

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Therefore, it is necessary to turn potassium iodide into a fine powder and mix with 3-4 g of a thick extract of licorice root. In this case, potassium iodide in a significant part will dissolve in the moisture of the extract. But it is impossible to obtain a proper pill mass from the extract alone, as it will be very viscous. Therefore, it is compacted with licorice powder, adding it little by little until a mass of appropriate plasticity is obtained.

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Pills with soluble and insoluble medicinal substances. More often, there are prescriptions, which simultaneously include soluble and insoluble (or hardly soluble) medicinal substances. For example, in the prescription of Shereshevsky's medrol pills (recipe 20.7):

Phenobarbital and methylthiouracil in the medrol pill mass manifest themselves as consistency substances. The missing amount of solid phase is compensated by the powder of valerian root. Potassium iodide is dissolved in 3-4 drops of water, after which iodine is dissolved (due to the frequent repetition of medrol recipe, for the convenience of work, a solution is prepared: 5 g I2 + 50 g KI and water to a volume of 100 ml; this solution is measured in drops according to the calculation).

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